Sonic hedgehog signaling is active in human adrenal cortex development and deregulated in adrenocortical tumors.

@article{Gomes2014SonicHS,
  title={Sonic hedgehog signaling is active in human adrenal cortex development and deregulated in adrenocortical tumors.},
  author={D{\'e}bora Cristiane Gomes and Let{\'i}cia Ferro Leal and L{\'i}via Mara Mermejo and Carlos Alberto Scrideli and Carlos Eduardo Martinelli and Maria C{\^a}ndida Villares Barisson Fragoso and Ana Claudia Latronico and Lu{\'i}s Gonzaga Tone and Silvio Junior Tucci and Jos{\'e} Andr{\'e}s Yunes and Izilda Aparecida Cardinalli and Maria J Mastellaro and S{\'i}lvia Regina Brandalise and Fernando Ramalho and Ayrton Cust{\'o}dio Moreira and Leandra N Z Ramalho and Margaret de Castro and Sonir Roberto Rauber Antonini},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2014},
  volume={99 7},
  pages={E1209-16}
}
BACKGROUND The sonic hedgehog (SHH) pathway plays a key role in rodent adrenal cortex development and is involved in tumorigenesis in several human tissues, but data in human adrenal glands are limited. OBJECTIVES The objectives of the study were to analyze the involvement of the SHH pathway in human adrenal development and tumorigenesis and the effects of SHH inhibition on an adrenocortical tumor (ACT) cell line. PATIENTS AND METHODS Expression of SHH pathway components was evaluated by… CONTINUE READING