Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells

@article{Wang2012SonicHR,
  title={Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells},
  author={Xianghong Wang and C Nimita Venugopal and Branavan Manoranjan and Nicole McFarlane and Erin O'Farrell and Stefanie Nolte and Thorsteinn Gunnarsson and Robert D Hollenberg and Jacek M Kwiecien and Paul D Northcott and Michael D. Taylor and Cynthia Hawkins and Sheila K Singh},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={187-199}
}
Bmi1 is a key stem cell regulatory gene implicated in the pathogenesis of many aggressive cancers, including medulloblastoma. Overexpression of Bmi1 promotes cell proliferation and is required for hedgehog (Hh) pathway-driven tumorigenesis. This study aimed to determine if Sonic hedgehog (Shh) modulates the key stem cell regulatory gene Bmi1 in childhood medulloblastoma brain tumor-initiating cells (BTICs). Although current literature suggests that there is a correlation between Shh pathway… CONTINUE READING
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Isolation of neural stem cells from the postnatal cerebellum

Nature Neuroscience • 2005
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