Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer.

@article{Li2014SonicHP,
  title={Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer.},
  author={Xuqi Li and Zheng Wang and Qingyong Ma and Qinhong Xu and Han Liu and Wanxing Duan and Jianjun Lei and Jiguang Ma and Xiu Wang and Shifang Lv and Liang Han and Wei Li and Jian Guo and Kun Guo and Dong Zhang and Erxi Wu and Keping Xie},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2014},
  volume={20 16},
  pages={4326-38}
}
PURPOSE Pancreatic cancer is characterized by stromal desmoplasia and perineural invasion (PNI). We sought to explore the contribution of pancreatic stellate cells (PSC) activated by paracrine Sonic Hedgehog (SHH) in pancreatic cancer PNI and progression. EXPERIMENTAL DESIGN In this study, the expression dynamics of SHH were examined via immunohistochemistry, real-time PCR, and Western blot analysis in a cohort of carcinomatous and nonneoplastic pancreatic tissues and cells. A series of in… CONTINUE READING

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