Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells.

@article{Yang2008SonicHI,
  title={Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells.},
  author={Liu Yang and Ying Wang and H. C. Mao and Susanne V Fleig and Alessia Omenetti and Kevin Brown and Jason Sicklick and Yinxiong Li and Anna Mae Diehl},
  journal={Journal of hepatology},
  year={2008},
  volume={48 1},
  pages={98-106}
}
BACKGROUND/AIMS Factors released during liver injury, such as platelet derived growth factor-BB (PDGF), promote accumulation of myofibroblastic hepatic stellate cells (MFB) that drive the pathogenesis of cirrhosis. The hedgehog (Hh) pathway regulates remodeling of other injured tissues. This study evaluates the hypothesis that autocrine production of Sonic hedgehog (Shh) promotes MFB growth. METHODS Primary rat hepatic stellate cells (HSC) were treated without or with PDGF, a pharmacologic… CONTINUE READING
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