Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation.

@article{SpinellaJaegle2001SonicHI,
  title={Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation.},
  author={Sylviane Spinella-Jaegle and Georges Rawadi and Sinichiro Kawai and Sylvie Gallea and Chi Faucheu and Patrick Mollat and B. Courtois and B. Bergaud and Valerie Ramez and Aline Blanchet and Guillaume Adelmant and R. Baron and Sergio Rom{\'a}n-Rom{\'a}n},
  journal={Journal of cell science},
  year={2001},
  volume={114 Pt 11},
  pages={
          2085-94
        }
}
The proteins of the hedgehog (Hh) family regulate various aspects of development. Recently, members of this family have been shown to regulate skeletal formation in vertebrates and to control both chondrocyte and osteoblast differentiation. In the present study, we analyzed the effect of Sonic hedgehog (Shh) on the osteoblastic and adipocytic commitment/differentiation. Recombinant N-terminal Shh (N-Shh) significantly increased the percentage of both the pluripotent mesenchymal cell lines… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

PTHrP reciprocally inhibits adipogenesis and enhances osteogenesis in pluripotent mesenchymal cells

G. K. Chan, D. Miao, +3 authors D. Goltzman
  • J . Bone Miner . Res .
  • 2000

Signaling of BMP4 and Sonic hedgehog in the early phase of fracture repair

K. Kuriyama, T. Nakase, +7 authors H. Yoshikawa
  • J . Bone Miner . Res .
  • 2000

Actions of hedgehog proteins on skeletal cells.

  • Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
  • 1999

Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1999

PTHrP inhibits adipogenesis by downregulating PPAR γ activity via MAP kinase signaling

G. K. Chan, A. C. Karaplis
  • J . Bone Miner . Res .
  • 1999