Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells.

@article{Yamazaki2008SonicHD,
  title={Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells.},
  author={Madoka Yamazaki and Kazumasa Nakamura and Yusuke Mizukami and Masaaki and Junpei Sasajima and Yoshiaki Sugiyama and Tomoya Nishikawa and Yoshikane Nakano and Nobuyuki Chigasaki Yanagawa and Kazuya Sato and Atsuo Maemoto and Satoshi Tanno and Toshikatsu Okumura and Hidenori Karasaki and Toru Asahikawa-shi Kono and Mikihiro Fujiya and Toshifumi Ashida and Daniel C. Chung and Yutaka Kohgo},
  journal={Cancer science},
  year={2008},
  volume={99 6},
  pages={
          1131-8
        }
}
Hedgehog signaling is important in the pathogenesis of pancreatic cancer. Several recent observations suggest the involvement of sonic hedgehog (SHH) in postnatal neovascularization. We identified a novel role for SHH in tumor-associated angiogenesis in pancreatic cancer. Immunohistochemical analysis revealed that patched homolog 1 (PTCH1), both a receptor for and transcriptional target of hedgehog signaling, was expressed in a small fraction of endothelial cells within pancreatic cancer, but… CONTINUE READING
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