Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development.

@article{Mfopou2007SonicHA,
  title={Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development.},
  author={Josu{\'e} Kunjom Mfopou and V{\'e}ronique De Groote and Xiabo Xu and Harry Heimberg and Luc Bouwens},
  journal={Stem cells},
  year={2007},
  volume={25 5},
  pages={1156-65}
}
Success of cell-replacement therapy for diabetes will largely depend on the establishment of alternative sources of pancreatic islet grafts. Embryonic stem (ES) cell differentiation toward pancreatic insulin-producing cells offers such perspectives, but there are still many challenges to overcome. Our previous studies suggested that the limited amount of insulin-positive cells derived from ES cells is related to the activation of pancreas inhibitory signals. To confirm this hypothesis, we… CONTINUE READING

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