Sonic hedgehog and bone morphogenetic protein 4 expressions in the hindgut region of murine embryos with anorectal malformations.

@article{Sasaki2004SonicHA,
  title={Sonic hedgehog and bone morphogenetic protein 4 expressions in the hindgut region of murine embryos with anorectal malformations.},
  author={Yasunari Sasaki and Naomi Iwai and Tomoki Tsuda and Osamu de Sandes Kimura},
  journal={Journal of pediatric surgery},
  year={2004},
  volume={39 2},
  pages={170-3; discussion 170-3}
}
PURPOSE The aim of this study was to determine the possible role of the retinoid-mediated signaling pathway in the pathogenesis of anorectal malformations (ARM). The authors investigated whether all-trans retinoic acid (ATRA) affects the expression pattern of Sonic hedgehog (Shh) and Bone morphogenetic protein 4 (BMP4), which play important roles in anorectal morphogenesis in vertebrates. METHODS Pregnant ICR strain mice were fed 100 mg/kg of ATRA on the ninth gestational day (E9). Embryos… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Morphogenesis and patterning of the phallus and cloaca in the American alligator, alligator mississippiensis.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation • 2015
View 6 Excerpts
Highly Influenced

Development of the cloaca, hemipenes, and hemiclitores in the green anole, Anolis carolinensis.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation • 2015
View 1 Excerpt

Associations of anorectal malformations and related syndromes

Pediatric Surgery International • 2013
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Birth defects and prenatal diagnosis, in Salder TW ed): Langman’s Medical Embryology

TW Salder
2003

TVN: Human birth defects, in Moore KL, ersaud TVN (eds): The Developing Human

KL Moore, Persaud
2003

PCW: The Vacterl association: Lessons from the onic hedgehog pathway

JH Kim, Kim
Clin Genet • 2001

Similar Papers

Loading similar papers…