Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance

@inproceedings{Avils2013SonicHA,
  title={Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance},
  author={Evelyn C. Avil{\'e}s and Nicole H. Wilson and Esther T Stoeckli},
  booktitle={Front. Cell. Neurosci.},
  year={2013}
}
As indicated by their name, morphogens were first identified for their role in the formation of tissues early in development. Secreted from a source, they spread through the tissue to form gradients by which they affect the differentiation of precursor cells in a concentration-dependent manner. In this context, the antagonistic roles of the morphogens of the Wnt family and Sonic hedgehog (Shh) in the specification of cell types along the dorso-ventral axis of the neural tube have been studied… CONTINUE READING