Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

@article{Echelard1993SonicHA,
  title={Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity},
  author={Yann Echelard and Douglas J. Epstein and Benoit St.-Jacques and Liya Shen and J. Dawson Mohler and Jill A. McMahon and Andrew P. McMahon},
  journal={Cell},
  year={1993},
  volume={75},
  pages={1417-1430}
}
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FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
TLDR
It is shown that a member of the FK506-binding protein family, FKBP8, is an essential antagonist of SHH signaling in CNS development, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development.
Life, death and Sonic hedgehog.
TLDR
Perturbation of SHH signaling after the early dorsoventral specification of the cranial neural tube leads to increased cell death in both the neural tube and the neural crest, which implies that SHH is continually required as a trophic and/or mitogenic factor during brain development, and expands the variety of cellular responses toSHH signaling.
Sonic hedgehog in CNS development: one signal, multiple outputs
Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1
Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
TLDR
It is shown that opb acts downstream of Shh, and data indicate that dorsalizing signals activate transcription of Rab23 in order to silence the Shh pathway in dorsal neural cells.
Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS.
TLDR
It is shown that the activity of one Shh enhancer, which directs reporter expression to portions of the ventral midbrain and diencephalon, overlaps both temporally and spatially with the expression of Sim2.
Medaka spalt acts as a target gene of hedgehog signaling.
TLDR
It is shown that the spalt expression domains expand in response to ectopic hedgehog activity and narrow in the presence of protein kinase A activity, an antagonist of hedgehog signaling, indicating that spalt is a hedgehog target gene.
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
TLDR
It is shown that Re can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly.
Regional Distribution of Sonic Hedgehog, Patched, and Smoothened mRNA in the Adult Rat Brain
TLDR
The data suggest that, besides its roles in determining cell fate and patterning during embryogenesis, the hedgehog signaling pathway may have also important roles in the adult brain.
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References

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TLDR
Sequence analysis reveals a motif characteristic of a transmembrane domain, suggesting that the hh protein is membrane-associated, and discusses the relationship between en and hh, and the role of the hH function.
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo
Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication.
Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila.
TLDR
Sequence analysis of the hedgehog locus suggests the protein product is a transmembrane protein, which may, therefore, be directly involved in cell-cell communication.
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
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TLDR
It is shown that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes, and that most other aspects of wG expression are independent of this regulatory network.
Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo
TLDR
It is demonstrated that the competence of cells to express wg is independent of their ability to receive the hh signal, and that wg activation requires the function of the segment polarity gene fused, suggesting that the putative hH signal is transduced by the serine/threonine kinase that fused encodes.
Sonic hedgehog mediates the polarizing activity of the ZPA
Role of the Drosophila patched gene in positional signalling
TLDR
It is shown that the role of patched in positional signalling is permissive rather than instructive, its activity being required to suppress wingless transcription in cells predisposed to express the latter.
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