Sonic Hedgehog as a mediator of long-range signaling.

@article{Goetz2002SonicHA,
  title={Sonic Hedgehog as a mediator of long-range signaling.},
  author={John A. Goetz and Liza M. Suber and Xin Zeng and David J Robbins},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2002},
  volume={24 2},
  pages={
          157-65
        }
}
  • John A. Goetz, Liza M. Suber, +1 author David J Robbins
  • Published in
    BioEssays : news and reviews…
    2002
  • Biology, Medicine
  • The ability of Hedgehog (Hh) proteins to exert their biological effects is regulated by a series of post-translational processes. These processes include an intramolecular cleavage, covalent addition of cholesterol and/or palmitate, and conversion into a multimeric freely diffusible form. The processing of Hh proteins affects their trafficking, potency, and ability to signal over many cell diameters. Accordingly, the loss of gene products required for these processes abrogates the Hh proteins… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 28 CITATIONS

    Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis.

    VIEW 3 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Cellular and Molecular Approaches to Regeneration and Repair

    Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions

    Exosomes in stroke pathogenesis and therapy.

    Function of neural stem cells in ischemic brain repair processes