Sonic Hedgehog and Other Soluble Factors from Differentiating Embryoid Bodies Inhibit Pancreas Development

  title={Sonic Hedgehog and Other Soluble Factors from Differentiating Embryoid Bodies Inhibit Pancreas Development},
  author={Josu{\'e} Kunjom Mfopou and V{\'e}ronique De Groote and Xiabo Xu and Harry Heimberg and Luc Bouwens},
  journal={STEM CELLS},
Success of cell‐replacement therapy for diabetes will largely depend on the establishment of alternative sources of pancreatic islet grafts. Embryonic stem (ES) cell differentiation toward pancreatic insulin‐producing cells offers such perspectives, but there are still many challenges to overcome. Our previous studies suggested that the limited amount of insulin‐positive cells derived from ES cells is related to the activation of pancreas inhibitory signals. To confirm this hypothesis, we… 

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