Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins.

@article{Polizio2011SonicHA,
  title={Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins.},
  author={Ariel H Polizio and Pilar Chinchilla and Xiaolen Chen and David R Manning and Natalia A. Riobo},
  journal={Science signaling},
  year={2011},
  volume={4 200},
  pages={
          pt7
        }
}
  • Ariel H Polizio, Pilar Chinchilla, +2 authors Natalia A. Riobo
  • Published in Science signaling 2011
  • Biology, Medicine
  • The vertebrate Hedgehog (Hh) pathway has essential functions during development and tissue homeostasis in normal physiology, and its dysregulation is a common theme in cancer. The Hh ligands (Sonic Hh, Indian Hh, and Desert Hh) bind to the receptors Patched1 and Patched2, resulting in inhibition of their repressive effect on Smoothened (Smo). Smo is a seven-transmembrane protein, which was only recently shown to function as a G protein-coupled receptor (GPCR) with specificity toward the… CONTINUE READING

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