Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.

@article{Malhotra2016SonicHS,
  title={Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.},
  author={Anshu Malhotra and Abhinav Dey and Niyathi Prasad and Anna Marie Kenney},
  journal={Molecular cancer research : MCR},
  year={2016},
  volume={14 1},
  pages={114-24}
}
UNLABELLED Sonic hedgehog (Shh) signaling is closely coupled with bioenergetics of medulloblastoma, the most common malignant pediatric brain tumor. Shh-associated medulloblastoma arises from cerebellar granule neuron precursors (CGNP), a neural progenitor whose developmental expansion requires signaling by Shh, a ligand secreted by the neighboring Purkinje neurons. Previous observations show that Shh signaling inhibits fatty acid oxidation although driving increased fatty acid synthesis… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 42 references

Acidic extracellular microenvironment and cancer

Cancer Cell International • 2013
View 1 Excerpt

Mitochondria and cancer

Nature Reviews Cancer • 2012
View 1 Excerpt

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