Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System

@article{Lu2000SonicHO,
  title={Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System},
  author={Q.Richard Lu and Dong-in Yuk and John A. Alberta and Zhimin Zhu and Inka Pawlitzky and Joanne P Chan and Andrew P. McMahon and Charles Dean Stiles and David H Rowitch},
  journal={Neuron},
  year={2000},
  volume={25},
  pages={317-329}
}
During development, basic helix-loop-helix (bHLH) proteins regulate formation of neurons from multipotent progenitor cells. However, bHLH factors linked to gliogenesis have not been described. We have isolated a pair of oligodendrocyte lineage genes (Olg-1 and Olg-2) that encode bHLH proteins and are tightly associated with development of oligodendrocytes in the vertebrate central nervous system (CNS). Ectopic expression of Olg-1 in rat cortical progenitor cell cultures promotes formation of… CONTINUE READING
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