Somnolence after prophylactic cranial irradiation in children with acute lymphoblastic leukaemia.

  title={Somnolence after prophylactic cranial irradiation in children with acute lymphoblastic leukaemia.},
  author={Jenny E Freeman and Patrick Gerard Johnston and Jennifer Voke},
  journal={British medical journal},
  volume={4 5891},
A transient cerebral disturbance characterized by somnolence of varying degree is described in children after cranial irradiation given as part of central nervous system (C.N.S.) prophylaxis for acute lymphoblastic leukaemia in remission.Out of 28 such children receiving cranial irradiation as part of the Medical Research Council protocol for C.N.S. prophylaxis 11 (39%) developed pronounced symptoms of somnolence, anorexia, and lethargy some six weeks after the completion of cranial irradiation… CONTINUE READING


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