• Corpus ID: 15640375

Something from “ Nothing ”-Eight Weak Estrogenic Chemicals Combined at Concentrations below NOECs Produce Significant Mixture Effects

  title={Something from “ Nothing ”-Eight Weak Estrogenic Chemicals Combined at Concentrations below NOECs Produce Significant Mixture Effects},
  author={E L I S A B E T E S I L V A and R E A S K O R T E N K A M P}
We tested whether multicomponent mixtures of xenoestrogens would produce significant effects when each component was combined at concentrations below its individual NOEC or EC01 level. The estrogenic effects of eight chemicals of environmental relevance, including hydroxylated PCBs, benzophenones, parabenes, bisphenol A, and genistein, were recorded using a recombinant yeast estrogen screen (YES). To ensure that no chemical contributed disproportionately to the overall combination effect, a… 

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