Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability

@article{Mitchison1987SomeTO,
  title={Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability},
  author={Timothy J Mitchison and Marc W Kirschner},
  journal={Cell Biophysics},
  year={1987},
  volume={11},
  pages={35-55}
}
We have considered the partitioning of tubulin between monomer and polymer in the cell under conditions of dynamic instability. Dynamic instability adds to the on and off rate constant of steady-state dynamics’ new parameters: (1) the rate at which growing microtubules transit to a shrinking phase; and (2) the rate at which shrinking microtubules transit to the growing phase. Under these conditions the free-monomer concentration in the cell increases with total tubulin if the number of… CONTINUE READING