Some practical improvements in the continual reassessment method for phase I studies.

@article{Goodman1995SomePI,
  title={Some practical improvements in the continual reassessment method for phase I studies.},
  author={Steven N. Goodman and Mariana L Zahurak and Steve Piantadosi},
  journal={Statistics in medicine},
  year={1995},
  volume={14 11},
  pages={1149-61}
}
The Continual Reassessment Method (CRM) is a Bayesian phase I design whose purpose is to estimate the maximum tolerated dose of a drug that will be used in subsequent phase II and III studies. Its acceptance has been hindered by the greater duration of CRM designs compared to standard methods, as well as by concerns with excessive experimentation at high dosage levels, and with more frequent and severe toxicity. This paper presents the results of a simulation study in which one assigns more… CONTINUE READING
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