Some physicochemical properties of FK906: glass transition and relaxation.

  title={Some physicochemical properties of FK906: glass transition and relaxation.},
  author={Jin Wook Jang and Shinichi Kitamura and J. Keith Guillory},
  journal={PDA journal of pharmaceutical science and technology},
  volume={49 1},
FK906, a tripeptide antihypertensive agent, was used as a model compound to study some physicochemical properties of peptides and peptide-related compounds. Our results indicate that lyophilization, grinding and melting or storing the samples under conditions of high relative humidity affect chemical stability and crystallinity of FK906. In a preliminary study of lyophilization process design, an extended phase diagram for FK906 in aqueous solution was constructed, and the effects of cooling… CONTINUE READING

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