Some pharmacological properties of N,N-disubstituted dithiocarbamates and their effect on the brain catecholamine levels.

  title={Some pharmacological properties of N,N-disubstituted dithiocarbamates and their effect on the brain catecholamine levels.},
  author={Jerzy G. Maj and Jerzy Vetulani},
  journal={European journal of pharmacology},
  volume={9 2},
  • J. Maj, J. Vetulani
  • Published 1 February 1970
  • Chemistry, Biology
  • European journal of pharmacology
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The compound had no effect on tremorine-induced tremor in mice and it was also ineffective towards amphetamine toxicity in aggregated mice, finding that diethyldithiocarbamate has certain depressing effects on the central nervous system.
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  • J. Littleton
  • Biology, Chemistry
    The Journal of pharmacy and pharmacology
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  • G. Chen, C. Ensor, B. Bohner
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    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1954
The drug hastens the onset of maximal tonic extensor seizures in mice receiving intravenous Metrazol or caffeine and lowers the convulsive seizure threshold of mice to electrical stimuli and antagonizes the anticonvulsant action of Dilantin.