Some pharmacological properties of N,N-disubstituted dithiocarbamates and their effect on the brain catecholamine levels.

@article{Maj1970SomePP,
  title={Some pharmacological properties of N,N-disubstituted dithiocarbamates and their effect on the brain catecholamine levels.},
  author={Jerzy G. Maj and Jerzy Vetulani},
  journal={European journal of pharmacology},
  year={1970},
  volume={9 2},
  pages={
          183-9
        }
}
  • J. Maj, J. Vetulani
  • Published 1 February 1970
  • Chemistry, Biology
  • European journal of pharmacology
Effect of amphetamine-type psychostimulants on brain metabolism.
  • C. Estler
  • Psychology
    Advances in pharmacology and chemotherapy
  • 1975
Sleeping with and without norepinephrine: effects of metoclopramide and D,L-threo-3,4-dihydroxyphenylserine on sleep in dopamine beta-hydroxylase deficiency.
TLDR
Data indicate that in patients with DBH deficiency norepinephrine is not essential for the development of a normal sleep/wake pattern but may have a facilitatory role in the generation of REM sleep.
Central Actions of Catecholamines
TLDR
Understanding of the anatomy and function of the noradrenergic and dopaminergic components of the central nervous system and development of substances which interfered with either the breakdown or synthesis of catecholamines showed remarkable strides.
Receptors and Other Targets for Toxic Substances
TLDR
It is proposed that TRI presents no significant human hepatocarcinogenic hazard since, (1) human hepatocyte produced TCA at a rate even lower than that of the rat, and (2) TCA was not a peroxisome proliferator in human hepatocytes.
Pesticide-drug interaction in rats.
TLDR
The possible interactions between a fungicide, thiram, and some drugs acting on the central nervous system were investigated in rats by means of behavioral methods and an additive interaction was observed in the case of trihexyphenidyl.
Enhanced Neurotransmitter Release by Pyrethroid Insecticides
TLDR
Type II pyrethroids may be acting as voltage-gated channel agonists in a manner consistent with their structure and activity relationship to the phenethylamine-type calcium channel blockers.
Role of 5‐hydroxytryptamine in ketamine‐induced hypothermia in the rat
TLDR
It is concluded that ketamine produces hypothermia in rats possibly through the release of 5‐hydroxytryptamine in the hypothalamus and that this effect is similar in some respects to that produced by morphine in non‐tolerant rats.
...
...

References

SHOWING 1-10 OF 20 REFERENCES
The effect of (±)‐p‐chloroamphetamine on the susceptibility to seizures and on the monoamine level in brain and heart of mice and rats
The effect of ( f)-p-chloroamphetamine on the susceptibility to seizures and on the monoamine level in brain and heart of mice and rats Sm,-In recent experiments we established that cr-methyldopa
Some central nervous properties of diethyldithiocarbamate
TLDR
The compound had no effect on tremorine-induced tremor in mice and it was also ineffective towards amphetamine toxicity in aggregated mice, finding that diethyldithiocarbamate has certain depressing effects on the central nervous system.
The interaction of dexamphetamine with inhibitors of noradrenaline biosynthesis in rat brain in vivo
  • J. Littleton
  • Biology, Chemistry
    The Journal of pharmacy and pharmacology
  • 1967
TLDR
A small dose of dexamphetamine (2 mg), which when administered alone caused no significant change in brain noradrenaline levels, reduced the rate of depletion of brain norADrenaline by both synthesis inhibitors when injected with them.
Disulfiram and the drug‐induced effects on motility
TLDR
The level of noradrenaline in the brain to be decreased without affecting or increasing only slightly, the level of dopamine and a similar preventive effect is obtained with disulfiram in mice given butyrophenones, and in these animals nialamide and dopa counteract sedation.
The role of brain serotonin in the mechanism of the central action of reserpine.
TLDR
Studies showing that 5-hydroxytryptophan (5-HTP) in doses that elicit excitation also causes the release of brain NE may remove a key argument against the view that reserpine acts through free 5-HT.
Diethyldithiocarbamate and amphetamine stereotype behaviour
TLDR
The effect of DDC is in sharp contrast to compounds which decrease the synthesis of both dopamine and noradrenaline by inhibition of the tyrosinehydroxylase (ct-methyltyrosine and some of its derivatives) to change the amphetamineinduced stereotype hyperactivity into a more varied behaviour, which besides sniffing includes locomotion and grooming.
A Facilitation Action of Reserpine on the Central Nervous System
  • G. Chen, C. Ensor, B. Bohner
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1954
TLDR
The drug hastens the onset of maximal tonic extensor seizures in mice receiving intravenous Metrazol or caffeine and lowers the convulsive seizure threshold of mice to electrical stimuli and antagonizes the anticonvulsant action of Dilantin.
...
...