Some newer concepts of the natural derivatives of hemoglobin; general considerations; the serum bilirubin and bilirubinuria; the erythrocyte protoporphyrin.

@article{Watson1946SomeNC,
  title={Some newer concepts of the natural derivatives of hemoglobin; general considerations; the serum bilirubin and bilirubinuria; the erythrocyte protoporphyrin.},
  author={Cecil James Watson},
  journal={Blood},
  year={1946},
  volume={1},
  pages={
          99-120
        }
}
The transition of hemoglobin to bile pigment, at least under normal conditions, is believed to occur via an intermediate biliverdin-globin-iron (verdohemoglobin) and not over the stages of hematin and protoporphyrin. It is probable that the next step is a reduction to bilirubin with splitting off of iron. There is much reason to believe that the globin remains attached until the bilirubin passes through the liver cell, bilirubinglobin exhibiting a delayed or indirect van den Bergh reaction and… Expand
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