Some new insights into the effects of opioids in phasic and tonic nociceptive tests

@article{McCormack1998SomeNI,
  title={Some new insights into the effects of opioids in phasic and tonic nociceptive tests},
  author={Keith McCormack and Paul L. Prather and Chris Chapleo},
  journal={Pain},
  year={1998},
  volume={78},
  pages={79-98}
}
In this review we critically appraise the value of some phasic and tonic nociceptive tests as models for differentiating the antinociceptive effects of opioid agonists. Using heat-evoked withdrawal of the hind paw or tail of a rodent, several early studies have assessed the effects of stimulus intensity upon antinociceptive potency of opioid agonists. After intrathecal (i.t.) administration of either morphine or sufentanil, for example, for any incremental change in stimulus intensity, the… CONTINUE READING

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