Some features of the spasmogenic actions of acetylcholine and histamine in guinea-pig isolated trachealis.

@article{Ahmed1984SomeFO,
  title={Some features of the spasmogenic actions of acetylcholine and histamine in guinea-pig isolated trachealis.},
  author={F Ahmed and Robert Wallace Foster and Roger C. Small and Arthur Henry Weston},
  journal={British journal of pharmacology},
  year={1984},
  volume={83 1},
  pages={
          227-33
        }
}
Intracellular electrophysiological recording showed that acetylcholine (1 mumol l-1) and histamine (2 mumol l-1) depolarized trachealis cells and often increased the frequency of slow waves. Higher concentrations of these agents caused greater depolarization and abolition of slow waves. Marked depolarization was often associated with the appearance of electrical 'noise'. These electrical phenomena were accompanied by tonic tension development in a contiguous segment of trachea. Electrical… CONTINUE READING