Some evolutionary consequences of deleterious mutations

  title={Some evolutionary consequences of deleterious mutations},
  author={Brian Charlesworth and Deborah Charlesworth},
Most mutations with observable phenotypic effects are deleterious. Studies of Drosophila and inbred plant populations suggest that a new individual may have a mean number of new deleterious mutations that exceeds one-half. Most of these have relatively small homozygous effects and reduce fitness by 1–2% when heterozygous. Several striking features of present-day organisms have apparently evolved in response to the constant input of deleterious alleles by recurrent mutation. For example, the… CONTINUE READING

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Mutation, mean fitness, and genetic load

J. F. Crow
Oxf. Surv. Evol. Biol • 1992
View 6 Excerpts
Highly Influenced

The maintenance of genetic variation in life- history traits,–xxx in evolutionary genetics from molecules to morphology, edited

B. Charlesworth, K. A. Hughes
View 4 Excerpts
Highly Influenced

The evolution of self fertilization and inbreeding depression in plants

D. W. Schemske
II. Empirical observations. Evolution • 1985
View 8 Excerpts
Highly Influenced

Benefits and handicaps of sexual reproduction

D. G. Lloyd
Evol. Biol • 1980
View 4 Excerpts
Highly Influenced

Demographic factors and mating patterns in angiosperms, pp. 67–88 in demography and evolution in plant populations, edited by O.T

D. G. Lloyd
View 4 Excerpts
Highly Influenced

Some reproductive factors affecting the selection of self-fertilization in plants

D. G. Lloyd
Am. Nat • 1979
View 5 Excerpts
Highly Influenced

The accumulation of deleterious genes in a population--Muller's Ratchet.

Theoretical population biology • 1978
View 7 Excerpts
Highly Influenced

Nature of deleterious mutation load in Drosophila.

Genetics • 1996
View 2 Excerpts
Highly Influenced

Linkage and the limits to natural selection.

Genetics • 1995
View 4 Excerpts
Highly Influenced

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