Some evolutionary consequences of deleterious mutations

@article{Charlesworth1998SomeEC,
  title={Some evolutionary consequences of deleterious mutations},
  author={Brian Charlesworth and Deborah Charlesworth},
  journal={Genetica},
  year={1998},
  volume={102},
  pages={3-19}
}
Most mutations with observable phenotypic effects are deleterious. Studies of Drosophila and inbred plant populations suggest that a new individual may have a mean number of new deleterious mutations that exceeds one-half. Most of these have relatively small homozygous effects and reduce fitness by 1–2% when heterozygous. Several striking features of present-day organisms have apparently evolved in response to the constant input of deleterious alleles by recurrent mutation. For example, the… CONTINUE READING

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