Some effects of metolazone on electrolyte transport.

  title={Some effects of metolazone on electrolyte transport.},
  author={B. Odlind and B. Beermann and B. Lindstr{\"o}m and O. Eriksson},
  journal={Upsala journal of medical sciences},
  volume={92 1},
Metolazone action was studied 1) in vitro on isolated operculum of Fundulus heteroclitus (active chloride transport) using an Ussing chamber (metolazone conc 500 microM) and in vivo 2) using the modified Sperber technique in the hen (metolazone infusion rate 0.75-1.2 micrograms/kg/min) and 3) in healthy volunteers using clearance techniques (metolazone infusion rate 10 mg/h). Metolazone reduced (p less than 0.05) short circuit current potential differences with 20% from average control values… Expand


Effects of metolazone in man: comparison with chlorothiazide.
The results indicate that metolazone exerts its major effect in the cortical diluting segment, but that it also possesses a proximal site of action. Expand
Effects of metolazone on renal function in normal man.
It was concluded that metolazone had no effect on the distal H + secretory mechanism and did not impair the ability to acidify normally the urine in response to an oral load of NH 4 Cl. Expand
Tubular secretion and effects of tienilic acid in the hen.
  • B. Odlind
  • Chemistry, Medicine
  • European journal of pharmacology
  • 1981
In the hen a significant part of the saluretic effect of tienilic acid depends on the active secretion of the drug by tubular cells, as has previously been found for three loop diuretics i.e. ethacrynic acid, furosemide and piretanide. Expand
The acute effects of metolazone on electrolyte and acid excretion in man
The decrease in urine pH and the absence of significant bicarbonaturia are evidence against carbonic anhydrase inhibition, which suggests that metolazone may somehow alter renovascular resistance at the time of maximal diuresis. Expand
Coupling between renal tubular secretion and effect of bumetanide
It is concluded that a large part of the diuretic effect of bumetanide depends on its active tubular secretion, as with furosemide and piretanide, which is elicited from the luminal side of the human nephron. Expand
Increase in diuretic effect of chlorothiazide by probenecid
  • D. Brater
  • Chemistry, Medicine
  • Clinical pharmacology and therapeutics
  • 1978
Doses of 500 mg and 1 gm of chlorothiazide (CTZ) intravenously to 5 volunteers with probenecid pretreatment increased 8‐hr rates of excretion of sodium and urine over that without probenicid, consistent with cn reaching its site of action from the peritubular side or that prolonged exposure of the lumen to lesser amounts of filtered CTZ causes a greater overall effect. Expand
Comparative study of the effects of metolazone and other diuretics on potassium excretion
Both metolazone and ethacrynic acid were much less kaliuretic than the carbonic anhydrase inhibitors: acetazolamide, furosemide, and chlorothiazide. Expand
Acute tolerance to furosemide diuresis in humans. Pharmacokinetic-pharmacodynamic modeling.
The time course of furosemide excretion, as well as the degree of renal compensation, determine the renal sensitivity to furoSemide, which has important implications for the proper design and interpretation of studies of the excretion-response relationship of diuretics. Expand
Renal tubular secretion of piretanide and its effects on electrolyte reabsorption and tubuloglomerular feedback mechanism.
The present results indicate that tubular secretion of piretanide is important for the diuretic response and that pireTanide inhibits the fluid absorption in the loop of Henle and the tubuloglomerular feedback control which would otherwise blunt the diUREtic response with a reduction in glomerular filtration rate. Expand
Diuretic effect and pharmacokinetics of tizolemide in subjects with normal and decreased renal function.
It remains to be assessed whether a full diuretic effect can be achieved in patients with renal insufficiency if higher doses are used and whether clinical trials with this drug in Patients with reduced renal function must take into account the expected prolongation of its half-life. Expand