Some correlations between procaine-induced convulsions and monoamines in the spinal cord of rats.

@article{Sawaki1989SomeCB,
  title={Some correlations between procaine-induced convulsions and monoamines in the spinal cord of rats.},
  author={Kohei Sawaki and Mitsuru Kawaguchi},
  journal={Japanese journal of pharmacology},
  year={1989},
  volume={51 3},
  pages={
          369-76
        }
}
The relationships between the convulsions induced by the local anesthetic procaine and monoamines in the spinal cord were investigated in rats. The levels of dopamine (DA) and serotonin (5-HT) in the spinal cord were time-dependently increased after procaine (170 mg/kg, i.p.), which induced clonic convulsions, but the level of norepinephrine (NE) was unchanged. The rats that died during convulsions had a marked increase in DA. Phenobarbital (25 mg/kg, s.c.) produced both depletion of DA and… 
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The results suggest that the GABA system may be involved in the mechanisms of local anesthetic-induced convulsions.
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The effects of gamma-aminobutyric acid on the induction of convulsions by local anesthetics were investigated in mice and rats and suggest that the GABA system may be involved in the mechanisms of local anesthetic-induced Convulsions.
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TLDR
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