Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord.

Abstract

The effects of local anesthetics (procaine and lidocaine) on the gamma-aminobutyric acid (GABA) and L-glutamic acid (Glu) levels in rat spinal cord were studied during the convulsive process. The present study also investigated the influence of central GABA manipulations on the local anesthetic-induced convulsions. An increase in spinal GABA levels was… (More)

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Cite this paper

@article{Sawaki1991SomeCB, title={Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord.}, author={K. Sawaki and K. Ouchi and T. Sato and Masahiko Kawaguchi}, journal={Japanese journal of pharmacology}, year={1991}, volume={56 3}, pages={327-35} }