Some aspects of IL‐8 pathophysiology III: chemokine interaction with endothelial cells

@article{Rot1996SomeAO,
  title={Some aspects of IL‐8 pathophysiology III: chemokine interaction with endothelial cells},
  author={A. Rot and E. Hub and J. Middleton and F. Pons and C. Rabeck and K. Thierer and Jonathan Wintle and B. Wolff and M. Zsak and P. Dukor},
  journal={Journal of Leukocyte Biology},
  year={1996},
  volume={59}
}
Chemolrines have been convincingly implicated in driving leukocyte emigration in different inflammatory reactions. However, the cellular and molecular mechanisms of chemokine involvement in leukocyte emigration are not yet clear. We and others suggested that leukocyte adhesion to the endothelium and transmigration are induced by chemokines immobilised on the endothelial cell surface. This would require the presence of specific chemokine binding sites in this microanatomical location. Using an… Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Binding of neutrophil attractant/activation protein-1 (interleukin 8) to resident dermal cells.
  • A. Rot
  • Biology, Medicine
  • Cytokine
  • 1992
TLDR
It is suggested that the NAP-1/IL-8-binding sites described here could be involved in the regulation of NAP’s 1,000-fold increase in neutrophil emigration. Expand
Leukocyte-endothelial adhesion molecules.
TLDR
Investigations have progressed from the early descriptions by intravital microscopy and histology, to functional and immunologic characterization of adhesion molecules, and now to the development of genetically deficient animals and the first phase I trial of "anti-adhesion" therapy in humans. Expand
IL-8 and angiogenesis: evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro.
TLDR
The data favour an indirect action for IL-8 as an angiogenic factor by examining interactions of recombinant humanIL-8 with cultured large vessel and microvascular human EC. Expand
The role of leukocyte chemotaxis in inflammation
The movement of leukocytes from blood into the tissues in response to inflammatory stimuli was observed and described as early as 1891 by Metchnikoff1 and 1888 by Leber2; however, only within theExpand
Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation.
TLDR
Results indicate that i.v.IL-8 can function as a PMN-directed leukocyte adhesion inhibitor and suggest that local secretion of IL-8 by activated endothelium may differentially modulate leukocytes-endothelial interactions at sites of acute inflammation. Expand
T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ
TLDR
It is proposed that MIP-1β and other cytokines with glycosaminoglycan-binding sites will bind to and be presented by endothelial proteoglycans to trigger adhesion selectively not only of lymphocyte subsets, but also of other cell types. Expand
Interleukin‐8 induces changes in human neutrophil actin conformation and distribution: relationship to inhibition of adhesion to cytokine‐activated endothelium
TLDR
It is suggested that the ability of IL‐8 and certain other leukocyte agonists to regulate the actin polymer network of neutrophils may play an important role in adhesive interactions with the vascular endothelium. Expand
The contributions of integrins to leukocyte infiltration in inflamed tissues.
  • T. Issekutz
  • Chemistry, Medicine
  • Current topics in microbiology and immunology
  • 1993
TLDR
In a number of models, leukocyte integrins appear to act at a second stage to greatly enhanceLeukocyte EC adhesion allowing the migration of the leukocytes along the EC and between ECs to the extracellular space. Expand
Neutrophil sequestration and migration in localized pulmonary inflammation. Capillary localization and migration across the interalveolar septum.
TLDR
Significant evidence supports the concept that leukocytes may emigrate into inflammatory lesions through the pulmonary capillary wall, quite unlike the situation in the systemic circulation where the predominant site of margination and emigration is the postcapillary venule. Expand
Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling.
TLDR
Findings show that IL-8 i.v. reduces granulocyte recruitment to inflammatory sites by inhibiting function(s) necessary for transmigration that are independent of L-selectin and subsequent to rolling. Expand
...
1
2
3
4
...