Some advantages of curing mice bearing a large subcutaneous MOPC-315 tumor with a low dose rather than a high dose of cyclophosphamide.

@article{Mokyr1983SomeAO,
  title={Some advantages of curing mice bearing a large subcutaneous MOPC-315 tumor with a low dose rather than a high dose of cyclophosphamide.},
  author={Margalit B. Mokyr and Sheldon Dray},
  journal={Cancer research},
  year={1983},
  volume={43 7},
  pages={3112-9}
}
Mice bearing a large s.c. MOPC-315 tumor can be cured by a dose of cyclophosphamide (CY) ranging from 15 to 200 mg/kg. However, the low (15 mg/kg) and the high (200 mg/kg) doses mediate tumor eradication via different mechanisms. Tumor eradication by the low dose of drug requires the cooperation of the toxic effect of the drug and T-cell-dependent antitumor immunity. On the other hand, tumor eradication by the high dose of drug does not require the participation of antitumor immunity but… CONTINUE READING

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In vitro immunization as a method for generating cytotoxic cells potentially useful in adoptive immunotherapy

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