Some Properties of Angiotensin Converting Enzyme in the Lung in vivo

@article{Ng1970SomePO,
  title={Some Properties of Angiotensin Converting Enzyme in the Lung in vivo},
  author={K. K. F. Ng and John Robert Vane},
  journal={Nature},
  year={1970},
  volume={225},
  pages={1142-1144}
}
THE lung has many important metabolic functions1,2 which include the selective activation or inactivation of endogenous peptides. Bradykinin is inactivated on transit through the pulmonary circulation3,4, probably by at least two endopeptidases5, but other peptides such as angiotensin II (refs. 6–10), polistes kinin11 and eledoisin3,4 pass through without loss. 
The Renin–Angiotensin System: Inhibition of Converting Enzyme in Isolated Tissues
The converting enzyme content of isolated tissues suggests that the indirect action of angiotensin I involves the intramural generation of angiotensin II. Inhibition of the enzyme shows that there is
Processing of Angiotensin and Other Peptides by the Lungs
TLDR
The sections in this article are Pulmonary Metabolism, Immunocytochemistry, Discussion and Future Directionsa, and Peptide Hormones.
The fate of circulating biologically active peptides in the lungs.
TLDR
Evidence is presented which supports the idea that when low doses of angiotensin I (greater than 10 ng) are given intravenously, most of the conversion is pulmonary, with higher doses, extrapulmonary conversion also contributes to the final pressor effect of angiotsin I.
ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS AND KININ METABOLISM: EVIDENCE THAT ACE INHIBITORS MAY INHIBIT A KININASE OTHER THAN ACE
  • D. Campbell
  • Biology, Chemistry
    Clinical and experimental pharmacology & physiology
  • 1995
TLDR
Findings suggest that increases in endogenous kinin levels may contribute to the therapeutic effects of ACE inhibitors.
Pharmacology of angiotensin converting enzyme inhibitors. A review.
History of the Development of Inhibitors of Angiotensin I Conversion
SummaryThe major steps in the initial development of angiotensin I conversion inhibitors are described, from the discovery of the Bothrops peptides (bradykinin potentiating factor) to the
Chemistry and Biologic Activity of Peptides Related to Bradykinin
TLDR
These new kinin analogs are tabulated in this chapter and the information gained from the study of these peptides is discussed and the attempts to make good peptide inhibitors of bradykinin are discussed.
Role of the lung in angiotensin metabolism.
  • M. Lubran
  • Biology, Medicine
    Annals of clinical and laboratory science
  • 1973
TLDR
The lungs, in addition to their central role in respiration, play an important part in the metabolism of some vasoactive sub­ stances, and the mechanism of the conversion forms the main theme of this paper.
...
...

References

SHOWING 1-10 OF 16 REFERENCES
Pulmonary activation of synthetic angiotensin I.
Fate of Angiotensin I in the Circulation
TLDR
The results of the blood-bathed organ technique do not support hypotheses which suggest a completely intra-renal role for the renin–angiotensin system.
Conversion of Angiotensin I to Angiotensin II by Cell-free Extracts of Dog Lung
TLDR
This communication describes some of the enzymes in extracts of dog lung that metabolize angiotensins I and II and particularly those catalysing the conversion ofAngiotensin I to angiotENSin II (“converting enzyme”) and the enzyme(s) responsible for the inactivation of ang Elliotensin II and angiotsin I are referred to as “destroying enzyme’.
Metabolism of the Angiotensins in Isolated Perfused Tissues
TLDR
Enzymes in isolated vascular beds can fully account for the metabolism of angiotensins I and II in vivo and may not be physiologically important.
Removal of angiotensins from the systemic circulation.
TLDR
It is concluded that the main process responsible for the clearing of angiotensin from the systemic circulation is not the activity of circulating angiotENSinases but rather occurs in the tissues.
THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the
Disappearance of Angiotensin from the Circulation of the Dog
TLDR
It is now clear that the blood itself plays little part in the inactivation of angiotensin and that the rapid removal of ang Elliotensin from the bloodstream occurs in the tissues through which it is carried.
Conversion of Angiotensin I to Angiotensin II
Results obtained with the blood bathed organ technique indicate that angiotensin I is converted rapidly to angiotensin II in the pulmonary circulation and not by an enzyme in the blood.
THE EXISTENCE OF TWO FORMS OF HYPERTENSIN
TLDR
Two types of hypertensin have been demonstrated by means of counter-current distribution and a highly purified preparation containing horse hypertensins I and II caused an elevation of blood pressure when injected into human beings.
Removal of Angiotensin by Isolated Perfused Organs of the Rat
Tissue peptidases are the enzymes chiefly responsible for the removal of angiotensin II in rat liver and kidney.
...
...