Some New Thoughts on the Pathophysiology and Genetics of Polycystic Ovary Syndrome

@article{Strauss2003SomeNT,
  title={Some New Thoughts on the Pathophysiology and Genetics of Polycystic Ovary Syndrome},
  author={Jerome F Strauss},
  journal={Annals of the New York Academy of Sciences},
  year={2003},
  volume={997}
}
  • J. Strauss
  • Published 2003
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Abstract: Polycystic ovary syndrome (PCOS) is a common disorder of unknown etiology, but several lines of evidence suggest that there is an underlying genetic cause for PCOS. Studies of first‐degree relatives of women diagnosed with PCOS reveal familial clustering of the disease, particularly hyperandrogenemia. A prospective study of first‐degree female relatives of PCOS women found that 46% of ascertainable sisters of PCOS women were hyperandrogenemic. The serum bioavailable testosterone in… Expand
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TLDR
It is likely that PCOS may represent the final outcome of different, deeply inter-related genetic abnormalities that influence each other and perpetuate the syndrome. Expand
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TLDR
Monkey models are most comprehensive, while mouse models provide molecular insight, including identifying the androgen receptor, particularly in neurons, as mediating androgen-induced PCOS-like programming. Expand
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TLDR
It is suggested that genetic and environmental factors play a role in the development of polycystic ovary syndrome and when the authors are able to identify and then modify environmental determinants, then the health of those patients who are predisposed to disease development due to genotype or previous environmental effects will be safeguarded better. Expand
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The pharmacologic characteristics of the different routes of progesterone administration with reference to these diverse indications, the therapeutic objectives and patient compliance are discussed. Expand
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Polycystic ovary syndrome (PCOS) is the most common and treatable endocrine dysfunction in fertile women. The pathophysiology of PCOS involves primary defects in the hypothalamic–pituitary axis,Expand
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TLDR
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FEM1A is a candidate gene for polycystic ovary syndrome
  • J. Maher, R. Hines, +8 authors B. Cowan
  • Biology, Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2005
TLDR
Immunostaining of mouse ovary demonstrated that the mouse homolog of FEM1A is expressed in androgen-producing secondary interstitial cells, with a marked increase in expression after puberty, consistent with a key feature of PCOS – ovarian hyperandrogenism. Expand
Studies to investigate a possible association between Polycystic Ovary Syndrome and Epithelial Ovarian Cancer
TLDR
The results of these studies do not provide convincing evidence of a correlation between PCOS and ovarian cancer. Expand
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