Some Isolated Cardiac Malformations Can Be Related to Laterality Defects

@article{Versacci2018SomeIC,
  title={Some Isolated Cardiac Malformations Can Be Related to Laterality Defects},
  author={P. Versacci and F. Pugnaloni and M. C. Digilio and Carolina Putotto and Marta Unolt and G. Calcagni and A. Baban and B. Marino},
  journal={Journal of Cardiovascular Development and Disease},
  year={2018},
  volume={5}
}
  • P. Versacci, F. Pugnaloni, +5 authors B. Marino
  • Published 2018
  • Medicine
  • Journal of Cardiovascular Development and Disease
  • Human beings are characterized by a left–right asymmetric arrangement of their internal organs, and the heart is the first organ to break symmetry in the developing embryo. Aberrations in normal left–right axis determination during embryogenesis lead to a wide spectrum of abnormal internal laterality phenotypes, including situs inversus and heterotaxy. In more than 90% of instances, the latter condition is accompanied by complex and severe cardiovascular malformations. Atrioventricular canal… CONTINUE READING
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    References

    SHOWING 1-10 OF 206 REFERENCES
    Molecular genetics of heterotaxy syndromes
    • 78
    Spectrum of Heart Malformations in Mice With Situs Solitus, Situs Inversus, and Associated Visceral Heterotaxy
    • 99
    • Highly Influential
    • PDF
    Abnormal Laterality and Congenital Cardiac Anomalies: Relations of Visceral and Cardiac Morphologies in the iv/iv Mouse
    • 98
    • Highly Influential
    • PDF
    Two rights make a wrong: human left-right malformations.
    • B. Casey
    • Medicine, Biology
    • Human molecular genetics
    • 1998
    • 124
    • Highly Influential
    • PDF
    CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle.
    • 179
    Genetics of human left-right axis malformations.
    • 112
    Transposition of Great Arteries: New Insights into the Pathogenesis
    • 63
    • PDF
    Familial transposition of the great arteries caused by multiple mutations in laterality genes
    • 108
    Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations.
    • 118
    • Highly Influential
    • PDF
    Atrioventricular defects--a study of 92 families.
    • 33
    • PDF