Some Isolated Cardiac Malformations Can Be Related to Laterality Defects

@inproceedings{Versacci2018SomeIC,
  title={Some Isolated Cardiac Malformations Can Be Related to Laterality Defects},
  author={Paolo Versacci and Flaminia Pugnaloni and Maria Christina Digilio and Carolina Putotto and Marta Unolt and Giulio Calcagni and Anwar Baban and Bruno Marino},
  booktitle={Journal of cardiovascular development and disease},
  year={2018}
}
Human beings are characterized by a left⁻right asymmetric arrangement of their internal organs, and the heart is the first organ to break symmetry in the developing embryo. Aberrations in normal left⁻right axis determination during embryogenesis lead to a wide spectrum of abnormal internal laterality phenotypes, including situs inversus and heterotaxy. In more than 90% of instances, the latter condition is accompanied by complex and severe cardiovascular malformations. Atrioventricular canal… CONTINUE READING
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Special Issue: Left-Right Asymmetry and Cardiac Morphogenesis

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  • 2018
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