Some GCR Polymorphisms (N363S, ER22/23EK, and Bcl-1) May Influence Steroid-induced Toxicities and Survival Rates in Children With ALL.

@article{Eipel2016SomeGP,
  title={Some GCR Polymorphisms (N363S, ER22/23EK, and Bcl-1) May Influence Steroid-induced Toxicities and Survival Rates in Children With ALL.},
  author={Oliv{\'e}r T. Eipel and Marta Z. Hegyi and Katalin Csord{\'a}s and Kriszt{\'i}na N{\'e}meth and Andrea Luczay and D{\'o}ra T{\"o}r{\"o}k and M{\'o}nika Cs{\'o}ka and D{\'a}niel J{\'a}nos Erd{\'e}lyi and G. P. Kov{\'a}cs},
  journal={Journal of pediatric hematology/oncology},
  year={2016},
  volume={38 5},
  pages={334-40}
}
We investigated whether an altered individual glucocorticoid sensitivity due to particular glucocorticoid receptor single-nucleotide polymorphisms (SNPs) (N363S, ER22/23EK, and Bcl-1) influences the susceptibility to steroid-related toxicities, prognostic factors, and survival rates in children with acute lymphoblastic leukemia. In total, 346 pediatric patients with acute lymphoblastic leukemia were enrolled in our study. Their carrier status was investigated by allele-specific polymerase chain… CONTINUE READING