Some Effects of a Hallucinogenic Compound (Cyprenorphine Hydrochloride; M 285) on the Light Reinforced Behaviour of Rats

@article{Lowe1969SomeEO,
  title={Some Effects of a Hallucinogenic Compound (Cyprenorphine Hydrochloride; M 285) on the Light Reinforced Behaviour of Rats},
  author={Geoff Lowe and D. I. Williams},
  journal={Nature},
  year={1969},
  volume={224},
  pages={1226-1226}
}
CYPRENORPHINE hydrochloride (M 285)1 is a morphine antagonist with greater potency (about 35 times) parenterally and longer duration of action than nalorphine. It has been surveyed for psychotomimetic effects in groups of five to ten pre-operative patients in the USA. After an intramuscular dose of 0.5 mg/kg about half claimed a “crazy feeling” or “seeing things”, usually with their eyes closed, and an irrational fear. These effects were more severe after 1.0 mg intramuscularly with distinct… 
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