Some Consequences of the RNA World Hypothesis

@article{Orgel2004SomeCO,
  title={Some Consequences of the RNA World Hypothesis},
  author={Leslie E. Orgel},
  journal={Origins of life and evolution of the biosphere},
  year={2004},
  volume={33},
  pages={211-218}
}
  • L. Orgel
  • Published 1 April 2003
  • Biology
  • Origins of life and evolution of the biosphere
It is now generally accepted that our familiar biological worldwas preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNAworld was the first biological world there is little that one canlearn from biochemistry about prebiotic chemistry, except that the formation and polymerization of nucleotides were once prebiotic processes. If the RNA world was not the first biological world, the above conclusion may not be justified, andone can… 
Prebiotic chemistry and the origin of the RNA world.
  • L. Orgel
  • Biology
    Critical reviews in biochemistry and molecular biology
  • 2004
TLDR
The demonstration that ribosomal peptide synthesis is a ribozyme-catalyzed reaction makes it almost certain that there was once an RNA World, and a discussion of genetic systems simpler than RNA that might have "invented" RNA is discussed.
RNA World: First Steps Towards Functional Molecules
This review is focused on the evolution of prebioticRNAmolecules’ from the first nucleotide’s origin towards the supramolecular complexes of RNA molecules, possessing the catalytic activities. On the
The Lipid-RNA World
TLDR
A 'Lipid-RNA World Scenario' based on the assumption that modern stable lipid-RNA interactions are molecular fossils of an ancient stage of evolution when RNA World originated from Lipid World is proposed, and an 'ice-covered hydrothermal vent' model of Hadean Ocean is presented.
The Lipid-RNA World: A Membrane Bound Origin of Ribosome
TLDR
A 'Lipid-RNA World Scenario' based on the assumption that modern stable lipid-RNA interactions are molecular fossils of an ancient stage of evolution when RNA World originated from Lipid World is proposed, and an 'ice-covered hydrothermal vent' model of Hadean Ocean is presented.
An alternative to the RNA World Hypothesis
TLDR
Ribosomal protein synthesis (RPS) evolved from coupled replication by using tRNAs and separating fidelity checking and peptide bond formation functions into small and large ribosomal subunits through the simple triplet-coded process into RPS.
RNA-mediated chemistries: a case of replication and capping
TLDR
An RNA-capping ribozyme is isolated and characterized that retains stereochemistry during the synthesis of a 5'-5' RNA cap, and oligonucleotides are found that are able to form transient unimolccular loop structures closed by 3s little as one base-pair to be viable substrates.
A ribonucleopeptide world at the origin of life
TLDR
This review covers the most recent and relevant scientific investigations that propose a better understanding of the ribonucleopeptide world hypothesis and the appearance of life and proposes two hypotheses for a primitive translation machinery that might have been formed of either a T box ribozyme or a ribopolymerase.
Depsipeptide nucleic acids: prebiotic formation, oligomerization, and self-assembly of a new candidate proto-nucleic acid
The mechanism by which genetic polymers spontaneously formed on the early Earth is currently unknown. The RNA World hypothesis implies that RNA oligomers were produced prebiotically, but the
A Model for the Origin of Protein Synthesis as Coreplicational Scanning of Nascent RNA
  • A. Yakhnin
  • Biology
    Origins of Life and Evolution of Biospheres
  • 2007
TLDR
This hypothesis explains a number of features of modern translation apparatus, such as the relative flexibility of genetic code, the number of proteins shared by the transcription and translation machines, the universal participation of an RNA subunit in co-translational protein secretion, ‘unscheduled translation’, and factor-independent translocation.
...
...

References

SHOWING 1-10 OF 25 REFERENCES
2 Prospects for Understanding the Origin of the RNA World
TLDR
The general idea that, in the development of life on the earth, evolution based on RNA replication preceded the appearance of protein synthesis was first proposed about 30 years ago and the existence of an RNA World as a precursor of the authors' DNA/protein world is a hypothesis.
The Genetic Code. The Molecular Basis for Genetic Expression
TLDR
To one who cannot find time to keep up with the spearhead papers of the leaders in this field yet finds the review articles insipid and overfamiliar, this book is a godsend.
The search and its outcome: high-resolution structures of ribosomal particles from mesophilic, thermophilic, and halophilic bacteria at various functional states.
  • A. Yonath
  • Biology, Chemistry
    Annual review of biophysics and biomolecular structure
  • 2002
TLDR
It is confirmed that the elements involved in intersubunit contacts and in substrate binding are inherently flexible and that a common ribosomal strategy is to utilize this conformational variability for optimizing its functional efficiency and minimizing nonproductive interactions.
Chemical Etiology of Nucleic Acid Structure: The α-Threofuranosyl-(3'→2') Oligonucleotide System
TLDR
Being derived from a sugar containing only four carbons, TNA is structurally the simplest of all potentially natural oligonucleotide-type nucleic acid alternatives studied thus far and warrants close scrutiny of the system in the context of the problem of RNA's origin.
The Primordial High Energy Compound: ATP or Inorganic Pyrophosphate?*
TLDR
The results suggest the presence of a latent nucleotide binding site aligned for a catalytic role in PPi-PFK, and it is proposed that the ancestral PFK was an ATP-dependent enzyme and that PPi/PFKs are a later evolving adaptation.
Coenzymes as fossils of an earlier metabolic state
  • H. White
  • Biology
    Journal of Molecular Evolution
  • 2005
TLDR
A metabolic system composed of nucleic acid enzymes is proposed to have existed prior to the evolution of ribosomal protein synthesis, rationalizing the fact that many coenzymes are nucleotide or heterocyclic bases which could be derived from nucleotides.
Polyphosphate metabolism in micro-organisms.
A production of amino acids under possible primitive earth conditions.
TLDR
In this study, an apparatus was built to circulate CHI4, NH3, H2O, and H2 past an electric discharge, and the resulting mixture has been tested for amino acids by paper chromatography.
PRODUCTION OF β-AMINO ACIDS
PROBLEM TO BE SOLVED: To simply obtain the subject compound by using readily obtainable raw materials and an inexpensive reagent by a few processes by introducing an eliminable group into a specific
Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules: an inventory for the origins of life
TLDR
Estimates of these sources for plausible end-member oxidation states of the early terrestrial atmosphere suggest that the heavy bombardment before 3.5 Gyr ago either produced or delivered quantities of organics comparable to those produced by other energy sources.
...
...