Some Consequences of the RNA World Hypothesis

@article{Orgel2004SomeCO,
  title={Some Consequences of the RNA World Hypothesis},
  author={Leslie E. Orgel},
  journal={Origins of life and evolution of the biosphere},
  year={2004},
  volume={33},
  pages={211-218}
}
  • L. Orgel
  • Published 2004
  • Biology, Medicine
  • Origins of life and evolution of the biosphere
It is now generally accepted that our familiar biological worldwas preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNAworld was the first biological world there is little that one canlearn from biochemistry about prebiotic chemistry, except that the formation and polymerization of nucleotides were once prebiotic processes. If the RNA world was not the first biological world, the above conclusion may not be justified, andone can… Expand
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Prebiotic chemistry and the origin of the RNA world.
  • L. Orgel
  • Biology, Medicine
  • Critical reviews in biochemistry and molecular biology
  • 2004
TLDR
The demonstration that ribosomal peptide synthesis is a ribozyme-catalyzed reaction makes it almost certain that there was once an RNA World, and a discussion of genetic systems simpler than RNA that might have "invented" RNA is discussed. Expand
The importance of prebiotic chemistry in the RNA world.
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These findings suggest that the sequences of living systems may have been determined in part by chance occurrences at origins, and the best way to understand origins is not by examining relatively unconstrained sequence information, but by examining the inherent constraints imposed by prebiotic chemistry. Expand
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Quadruplex World.
  • Besik Kankia
  • Medicine
  • Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life
  • 2021
TLDR
This paper describes a fundamentally different idea: the de novo appearance of a nucleic acid polymer without any preexisting rules or requirements, coined as the quadruplex world hypothesis, based on the ability of guanines to form stable G-tetrads that facilitate polymerization and the unique property of polyguanine to fold into a monomolecular tetrahelix. Expand
The Lipid-RNA World
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A 'Lipid-RNA World Scenario' based on the assumption that modern stable lipid-RNA interactions are molecular fossils of an ancient stage of evolution when RNA World originated from Lipid World is proposed, and an 'ice-covered hydrothermal vent' model of Hadean Ocean is presented. Expand
The Lipid-RNA World: A Membrane Bound Origin of Ribosome
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A 'Lipid-RNA World Scenario' based on the assumption that modern stable lipid-RNA interactions are molecular fossils of an ancient stage of evolution when RNA World originated from Lipid World is proposed, and an 'ice-covered hydrothermal vent' model of Hadean Ocean is presented. Expand
Introns: Mighty Elements from the RNA World
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P peculiarities in the RNA-protein world are explored and it is demonstrated that these peculiarities could shed light on introns’ original functions as well as the important role they might have played in the origin of life. Expand
An alternative to the RNA World Hypothesis
TLDR
Ribosomal protein synthesis (RPS) evolved from coupled replication by using tRNAs and separating fidelity checking and peptide bond formation functions into small and large ribosomal subunits through the simple triplet-coded process into RPS. Expand
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Our current understanding of biology suggests that early life relied predominantly on RNA for both catalysis and the storage of genetic information. Tremendous efforts have been undertaken to confirm… Expand
A ribonucleopeptide world at the origin of life
TLDR
This review covers the most recent and relevant scientific investigations that propose a better understanding of the ribonucleopeptide world hypothesis and the appearance of life and proposes two hypotheses for a primitive translation machinery that might have been formed of either a T box ribozyme or a ribopolymerase. Expand
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