Some Consequences of the RNA World Hypothesis

@article{Orgel2004SomeCO,
  title={Some Consequences of the RNA World Hypothesis},
  author={Leslie E. Orgel},
  journal={Origins of life and evolution of the biosphere},
  year={2004},
  volume={33},
  pages={211-218}
}
  • L. Orgel
  • Published 1 April 2003
  • Biology
  • Origins of life and evolution of the biosphere
It is now generally accepted that our familiar biological worldwas preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNAworld was the first biological world there is little that one canlearn from biochemistry about prebiotic chemistry, except that the formation and polymerization of nucleotides were once prebiotic processes. If the RNA world was not the first biological world, the above conclusion may not be justified, andone can… 
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  • 2004
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The demonstration that ribosomal peptide synthesis is a ribozyme-catalyzed reaction makes it almost certain that there was once an RNA World, and a discussion of genetic systems simpler than RNA that might have "invented" RNA is discussed.
The importance of prebiotic chemistry in the RNA world.
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This review is focused on the evolution of prebioticRNAmolecules’ from the first nucleotide’s origin towards the supramolecular complexes of RNA molecules, possessing the catalytic activities. On the…
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A 'Lipid-RNA World Scenario' based on the assumption that modern stable lipid-RNA interactions are molecular fossils of an ancient stage of evolution when RNA World originated from Lipid World is proposed, and an 'ice-covered hydrothermal vent' model of Hadean Ocean is presented.
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A 'Lipid-RNA World Scenario' based on the assumption that modern stable lipid-RNA interactions are molecular fossils of an ancient stage of evolution when RNA World originated from Lipid World is proposed, and an 'ice-covered hydrothermal vent' model of Hadean Ocean is presented.
An alternative to the RNA World Hypothesis
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Ribosomal protein synthesis (RPS) evolved from coupled replication by using tRNAs and separating fidelity checking and peptide bond formation functions into small and large ribosomal subunits through the simple triplet-coded process into RPS.
RNA-mediated chemistries: a case of replication and capping
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This review covers the most recent and relevant scientific investigations that propose a better understanding of the ribonucleopeptide world hypothesis and the appearance of life and proposes two hypotheses for a primitive translation machinery that might have been formed of either a T box ribozyme or a ribopolymerase.
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The mechanism by which genetic polymers spontaneously formed on the early Earth is currently unknown. The RNA World hypothesis implies that RNA oligomers were produced prebiotically, but the…
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  • Biology
    Origins of Life and Evolution of Biospheres
  • 2007
TLDR
This hypothesis explains a number of features of modern translation apparatus, such as the relative flexibility of genetic code, the number of proteins shared by the transcription and translation machines, the universal participation of an RNA subunit in co-translational protein secretion, ‘unscheduled translation’, and factor-independent translocation.
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