Some Compounds in the Carbanilide Series Preventing Shell Porphyrin Deposition

@article{Polin1959SomeCI,
  title={Some Compounds in the Carbanilide Series Preventing Shell Porphyrin Deposition},
  author={Donald Polin and Arthur J. Basso and R. C. O'neill},
  journal={Poultry Science},
  year={1959},
  volume={38},
  pages={282-284}
}
Abstract PROTOPORPHYRIN deposition on egg shells is markedly decreased by feeding laying hens a ration containing nicarbazin, a complex of 4,4′-dinitrocarbanilide (DNC) and 2-hydroxy-4,6-dimethyl pyrimidine (HDP). (For figure of molecular configuration see Cuckler et al., 1955, or Ott et al., 1956.) There is no effect on shell weight, only an effect on shell color (McClary, 1955; Ott et al., 1955, 1956; Sherwood et al., 1956; Polin and Porter, 1956; Cuckler et al., 1957; McLoughlin et al., 1957… 
3 Citations
Downregulation of ALAS1 by nicarbazin treatment underlies the reduced synthesis of protoporphyrin IX in shell gland of laying hens
TLDR
It is demonstrated that nicarbazin feeding down-regulated ALAS1 and reduced protoporphyrin IX (PP IX) in both shell gland and eggshell, indicating the role of nicarbAZin in inhibiting the synthesis of PP IX.
RED, WHITE, AND BLUE EGGS AS MODELS OF PORPHYRIN AND HEME METABOLISM *
TLDR
A fascinating discussion of “The Races of Domestic Fowl” appeared almost one-half century ago in the National Geographic magazine, and it is clear that color of egg shells is determined by a mixture of pigments.
Studies on egg shell pigmentation in the domestic fowl Gallus Domesticus
TLDR
The results presented in this thesis confirm that in brown eggs laid by the domestic hen the intensity of colour depends on the amount of protoporphyrin-IX in the egg shell, and it is suggested that selection for dark shells may be of practical value when wishing to improve shell strength.

References

SHOWING 1-6 OF 6 REFERENCES
Biological Studies on Nicarbazin, a New Anticoccidial Agent
Abstract NICARBAZIN, an equimolecular complex of 4,4′-dinitrocarbanilide and 2-hydroxy-4,6-dimethylpyrimidine, has been studied extensively and found to be an effective anticoccidial agent for
The Effect of Nicarbazin on Reproduction in White Rock Breeder Hens
TLDR
NICARBAZIN—a molecular complex of 4, 4′-dinitrocarbanilide and 2-hydroxy-4, 6-dimethylpyrimidine—became widely used during 1955 as a coccidiostat for starting and growing chicks and did not interfere with sexual maturity, egg production and fertility in adult chickens.
The Restriction of Ooporphyrin Deposition on Egg Shells by Drug Feeding
Abstract The development, through research, of new growth stimulants and drugs for disease and parasite preventives and treatments in poultry might be expected to result in some “accidental”
Egg Shell Color and Egg Production in New Hampshire Laying Hens as Affected by Nicarbazin Medication
TLDR
NICarbazin effectively controls experimentally induced coccidiosis in chickens and does not interfere with sexual maturity, egg production, or egg fertility.
Antagonistic Effect of Thiocarbanilide on 4,4′-Dinitrocarbanilide, A Component of Nicarbazin
TLDR
Thiocarbanilide effectively inhibited the anticoccidial activity of nicarbazin when given parenterally as well as orally and antagonized the effect of nic Barbazin on the depigmentation of egg shell color.