Some Characteristics of an Exceptionally Potent Inhaled Anesthetic: Thiomethoxyflurane

  title={Some Characteristics of an Exceptionally Potent Inhaled Anesthetic: Thiomethoxyflurane},
  author={Yasumasa Tanifuji and Edmond I. Eger and Ross C. Terrell},
  journal={Anesthesia \& Analgesia},
The authors sought to test whether a deviation existed for the correlation between anesthetic potency and the oil/gas partition coefficient at an extreme of lipid solubility. For thiomethoxyflurane, the sulfur analog of methoxyflurane, the oil/gas partition coefficient was 7230 ± 50 SEM, and MAC (minimum alveolar concentration of thiomethoxyflurane required for anesthesia) in 4 dogs was 0.035 ± 0.008 percent of 1 atm. This agrees with the potency predicted by the lipid solubility, although… Expand
Halogenation and Anesthetic Potency
This product is significantly less than that for other inhaled anesthetics, a finding which either challenges the unitary theory of narcosis or suggests that the lipid solvent classically used to model the site of anesthetic action (olive oil) is inappropriate. Expand
Are Convulsant Gases Also Anesthetics?
The increase of isoflurane requirement in dogs at lower concentrations of flurothyl suggests that anesthetics with a potential to cause convulsions may partly antagonize their own anesthetic effect. Expand
Partition Coefficients of I‐653 in Human Blood, Saline, and Olive Oil
  • E. Eger
  • Medicine
  • Anesthesia and analgesia
  • 1987
Values indicate that I-653 will have a minimum alveolar concentration (MAC) required for anesthesia that is four to five times that of isoflurane and that it will produce a rapid induction of and recovery from anesthesia. Expand
Partitioning of four modern volatile general anesthetics into solvents that model buried amino acid side-chains.
The results suggest that volatile general anesthetics interact better with partly polar groups, which are present on amino acids frequently found buried in the hydrophobic core of proteins, compared to purely aliphatic side-chains. Expand
Membrane stabilizing action of NCO-650 and its congeners.
NCO-650 was found to show the greatest hemolysis protection, reduction of the surface tension and depression of the phase-transition temperature, indicating that it possesses a significant affinity to cell membranes and a significant ability to stabilize cell membranes. Expand
Future Development of Volatile Anesthetics
Inhalation anesthetics have been known for a very long time and ether, originally called sweet vitriol, was discovered by Valerius Cordus in 1540 and used by Giambattista Delia Porta in 1581, but it was not employed for any type of surgical anesthesia. Expand
GAS-1: a mitochondrial protein controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans.
The finding that mutations in complex I increase sensitivity of C elegans to volatile anesthetics may implicate this physiologic process in the determination of anesthetic sensitivity. Expand
Chapter 39 General anesthetics
This chapter describes several major requirements of contemporary anesthetic management that must be met by anesthetic drugs or combinations of agents, and presents hypotheses that have been proposed for the mechanism of anesthesia. Expand
C. elegans and volatile anesthetics.
Genes and gene sets that control the behavior of the animal in volatile anesthetics have been identified, using multiple endpoints to mimic the phenomenon of anesthesia in man. Expand
Isoflurane Selectively Inhibits Distal Mitochondrial Complex I in Caenorhabditis Elegans
Isoflurane directly inhibits complex I at a site distal to the flavoprotein subcomplex, however, this work has excluded the original hypothesis that isoflurane and ubiquinone compete for a common hydrophobic binding site on complex I. Expand


Minimum Alveolar Concentrations of Methoxyflurane, Halothane, Ether and Cyclopropane in Man: Correlation with Theories of Anesthesia
MAC as a measure of anesthetic potency correlates better with Iipid solubility than with any other physical constant and should be considered when the primary site of anesthesia action within the brain is sought. Expand
Studies with 14 compounds indicate that the passage of drugs into cerebrospinal fluid (CSF) is governed mainly by two physical properties: the degree of ionization of the drug; and theExpand
The anaesthetic pressures of certain fluorine-containing gases.
The correlation of anaesthetic pressure with olive oilsolubility (Meyer-Overton hypothesis) is shown to be superior to that with hydrate dissociation pressure and the best solubility correlation is obtained with solvents of solubilities parameter 9 ± 1.4. Expand
Is the End‐tidal Anesthetic Partial Pressure an Accurate Measure of the Arterial Anesthetic Partial Pressure?
Ninety-four sets of inspired, end-tidal and arterial samples were drawn from 17 human subjects anesthetized with halothane in oxygen or halothsane in nitrous oxide, finding that the difference between the arterial and end-Tidal partial pressures was a fifth of the difference Between end- tidal and inspired partial pressures. Expand
Anesthetic uptake and action
Find loads of the anesthetic uptake and action book catalogues in this site as the choice of you visiting this page. You can also join to the website book library that will show you numerous booksExpand
Mechanisms of general anesthesia, Anesthetic Uptake and Action
  • Edited by E I Eger 11. Baltimore, The Williams & Wilkins Company,
  • 1974
DDW: The anesthetic effects of inert gases
  • American Society of Anesthesiologists Annual Meeting, Abstracts of Scientific Papers,
  • 1972
The anesthetic effects of inert gases
  • American Society of Anesthesiologists Annual Meeting , Abstracts of Scientific Papers
  • 1972
Anaesthetics, Handbook of Neurochemistry. Edited by A Lajtha
  • 1971
Anesthetic potencies of sulfur hexafluride, carbon tetrafluride, chloroform and Ethrane in dogs
  • Anesthesiology
  • 1969