Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.

@article{Bartke2013SomatotropicST,
  title={Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.},
  author={Andrzej Bartke and Liou Y Sun and Valter D Longo},
  journal={Physiological reviews},
  year={2013},
  volume={93 2},
  pages={
          571-98
        }
}
Growth hormone (GH) is a key determinant of postnatal growth and plays an important role in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling delays aging and remarkably extends longevity in laboratory mice. In GH-deficient and GH-resistant animals, the "healthspan" is also extended with delays in cognitive decline and in the onset of age-related disease. The role of hormones homologous to insulin-like growth factor (IGF, an important mediator of GH… CONTINUE READING

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