Somatostatin through its specific receptor inhibits spontaneous and TNF-alpha- and bacteria-induced IL-8 and IL-1 beta secretion from intestinal epithelial cells.

@article{Chowers2000SomatostatinTI,
  title={Somatostatin through its specific receptor inhibits spontaneous and TNF-alpha- and bacteria-induced IL-8 and IL-1 beta secretion from intestinal epithelial cells.},
  author={Yehuda Chowers and Liora Cahalon and Michal Lahav and Heloisa H. R. Schor and Ruth Tal and Simon Bar-Meir and Mia Levite},
  journal={Journal of immunology},
  year={2000},
  volume={165 6},
  pages={
          2955-61
        }
}
Intestinal epithelial cells secrete proinflammatory cytokines and chemokines that are crucial in mucosal defense. However, this secretion must be tightly regulated, because uncontrolled secretion of proinflammatory mediators may lead to chronic inflammation and mucosal damage. The aim of this study was to determine whether somatostatin, secreted within the intestinal mucosa, regulates secretion of cytokines from intestinal epithelial cells. The spontaneous as well as TNF-alpha- and Salmonella… CONTINUE READING

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