Somatostatin secretion and action in the regulation of growth hormone secretion.

Abstract

The inhibition of growth hormone (GH) secretion by the hypothalamic peptide, somatostatin, is mediated by two critical factors: the concentration of the peptide in hypothalamic portal plasma and the number of somatostatin (SRIF) receptors on the somatotroph. The secretory patterns of SRIF and GH-releasing hormone (GRH) in portal blood of unanesthetized… (More)

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