Somatostatin receptors and somatostatin content in medullary thyroid carcinomas.

  title={Somatostatin receptors and somatostatin content in medullary thyroid carcinomas.},
  author={Jean Claude Reubi and Jean Alain Chayvialle and Brigitte Franc and R{\'e}gis Cohen and Claude Calmettes and Elizabeth Modigliani},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={64 4},
Human medullary thyroid carcinomas from 19 patients were analyzed for their content in somatostatin (SRIF) receptors using receptor autoradiography with a SRIF-28 analogue and the SRIF octapeptide [Tyr3]-SMS 201-995 as iodinated radioligands. Four out of 19 cases were SRIF receptor positive with the SRIF octapeptide radioligand. These cases as well as four additional tumors were also positive with the SRIF-28 radioligand 125I-[Leu8, D-Trp22, Tyr25]-SRIF-28. High affinity binding sites… CONTINUE READING

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