Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice.

@article{Moneta2002SomatostatinRS,
  title={Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice.},
  author={Daniela Moneta and Cristina Richichi and Marisa Aliprandi and Pascal Dournaud and Patrick Dutar and J. M. Billard and Antonio Scotto Di Carlo and C{\'e}cile Viollet and Jason P. Hannon and Dominique Fehlmann and Caroline Nunn and Daniel Hoyer and Jacques Epelbaum and Annamaria Vezzani},
  journal={The European journal of neuroscience},
  year={2002},
  volume={16 5},
  pages={
          843-9
        }
}
We have investigated the role of somatostatin receptor subtypes sst2 and sst4 in limbic seizures and glutamate-mediated neurotransmission in mouse hippocampus. As compared to wild-type littermates, homozygous mice lacking sst2 receptors showed a 52% reduction in EEG ictal activity induced by intrahippocampal injection of 30 ng kainic acid (P < 0.05). The number of behavioural tonic-clonic seizures was reduced by 50% (P < 0.01) and the time to onset of seizures was doubled on average (P < 0.05… CONTINUE READING

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