Somatostatin inhibits prolactin secretion by multiple mechanisms involving a site of action distal to increased cyclic adenosine 3',5'-monophosphate and elevated cytosolic Ca2+ in rat lactotrophs.

Abstract

The release of prolactin (PRL) from a clonal cell-line of anterior pituitary cells (GH4C1) was inhibited by somatostatin (SRIH) in a dose-dependent manner (ED50 nM). The inhibition (20% of control levels) was detectable within 50 s and maximal within 90 s. Thyroliberin (TRH) enhancement of PRL secretion was biphasic. SRIH inhibited both phases equally… (More)

Topics

Cite this paper

@article{Bjro1988SomatostatinIP, title={Somatostatin inhibits prolactin secretion by multiple mechanisms involving a site of action distal to increased cyclic adenosine 3',5'-monophosphate and elevated cytosolic Ca2+ in rat lactotrophs.}, author={Trine P Bj\oro and B C Ostberg and Olav Sand and P. A. Torjesen and Emily Jane Penman and Jan Oxholm Gordeladze and Johan Iversen and Kaare M. Gautvik and E. Haug}, journal={Acta physiologica Scandinavica}, year={1988}, volume={133 3}, pages={271-82} }