Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells.

@article{Heisler1982SomatostatinIM,
  title={Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells.},
  author={Seymour Heisler and Terry David Reisine and Vivian Hook and Julius Axelrod},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 21},
  pages={
          6502-6
        }
}
The AtT-20/D16-16 mouse pituitary tumor cell secretes corticotropin (ACTH) in response to corticotropin-releasing factor (CRF), (-)-isoproterenol, and vasoactive intestinal peptide (VIP). These responses are associated with a rapid increase in cyclic AMP formation. Somatostatin (SRIF) markedly decreases the stimulatory effect of CRF, (-)-isoproterenol, and VIP on both cyclic AMP formation and immunoreactive ACTH secretion. Forskolin and cholera toxin, adenylate cyclase activators, also… CONTINUE READING
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