Somatostatin inhibits basal and growth hormone-stimulated hepatic insulin-like growth factor-I production.

@article{Very2008SomatostatinIB,
  title={Somatostatin inhibits basal and growth hormone-stimulated hepatic insulin-like growth factor-I production.},
  author={Nicole M Very and Jeffrey D. Kittilson and Sarah E Klein and Mark A. Sheridan},
  journal={Molecular and cellular endocrinology},
  year={2008},
  volume={281 1-2},
  pages={19-26}
}
Growth of vertebrates is controlled by the growth hormone (GH)-insulin-like growth factor-I (IGF-I) system, and somatostatins (SSs) have been shown to inhibit growth by reducing the release of growth hormone (GH) from the pituitary. In this study, we used rainbow trout to assess the effects of SSs on the production of IGF-I. Somatostatin-14 (SS-14-I) implantation for 15 days significantly reduced steady-state levels of IGF-I mRNA in liver and lowered IGF-I concentration in plasma compared to… CONTINUE READING

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