Somatostatin inhibition of phosphoinositides turnover in isolated rat acinar pancreatic cells: interaction with bombesin

@article{Linard1992SomatostatinIO,
  title={Somatostatin inhibition of phosphoinositides turnover in isolated rat acinar pancreatic cells: interaction with bombesin},
  author={C. Linard and F. Reyl-Desmars and M. Lewin},
  journal={Regulatory Peptides},
  year={1992},
  volume={41},
  pages={219-226}
}
The effects of somatostatin-14 and bombesin on [3H]inositol phosphate accumulation were studied in 24 h myo-[3H]inositol-prelabeled cultured rat acinar cells. Bombesin, 10 nM, stimulated basal formation of phosphatidyl monophosphate (InsP1), phosphatidyl 4,5-biphosphate (InsP2) and inositol 1,4,5-triphosphate (InsP3) by 128 +/- 5.2%, 147 +/- 10% and 155 +/- 5%, respectively. At 5 s, the ED50 value for InsP3 stimulation was 0.70 +/- 0.2 nM. This stimulation was partly blocked (64 +/- 0.04… Expand
Parietal Cell Receptors of Acid Secretion
Somatostatin: One of the Rare Multifunctional Inhibitors of Mammalian Species.
Cellular biology of somatostatin receptors
Parietalzellrezeptoren und Magensekretion
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