Somatostatin inhibition of VIP-induced somatostatin release, cyclic AMP accumulation and 45Ca2+ uptake in diencephalic cells.

@article{ParsHerbut1989SomatostatinIO,
  title={Somatostatin inhibition of VIP-induced somatostatin release, cyclic AMP accumulation and 45Ca2+ uptake in diencephalic cells.},
  author={N{\'u}ria Par{\'e}s-Herbut{\'e} and Jos{\'e} D{\'i}az and Helene Thefenne Astier and Lucia Tapia-Arancibia},
  journal={European journal of pharmacology},
  year={1989},
  volume={161 2-3},
  pages={241-4}
}
The effect of somatostatin (SRIF) on VIP induction of SRIF secretion, cyclic AMP accumulation and 45Ca2+ influx was investigated in cultured diencephalic cells. [D-Trp8]SRIF suppressed VIP-stimulated SRIF release and decreased VIP-stimulated cyclic AMP accumulation in a dose-dependent manner. SRIF-14 blocked basal and VIP-stimulated 45Ca2+ entry into cells. The data suggest that the inhibitory effect of SRIF on VIP-induced SRIF release is partly due to a decrease in Ca2+ entry into cells. 

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