Somatostatin inhibition of VIP- and isoproterenol-stimulated cyclic AMP production in rat peritoneal macrophages

@article{Segura1992SomatostatinIO,
  title={Somatostatin inhibition of VIP- and isoproterenol-stimulated cyclic AMP production in rat peritoneal macrophages},
  author={Juan Jos{\'e} Segura and Juan Miguel Montalvo Guerrero and Raimundo Goberna and Juan Ram{\'o}n Calvo},
  journal={Neuropeptides},
  year={1992},
  volume={23},
  pages={39-43}
}
The dual regulation of cyclic AMP levels in rat peritoneal macrophages incubated with somatostatin, vasoactive intestinal peptide (VIP), and isoproterenol was studied. Somatostatin exerted a non-competitive inhibition of the stimulatory effect of VIP and isoproterenol on cyclic AMP production. In addition, somatostatin inhibited basal cyclic AMP levels. Our results suggest that somatostatin and VIP may modulate the immune response acting, through cyclic AMP, on macrophage functions. 

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References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

19 . Immunomodulation by somatostatin

B. Radosevic-Stasic, M. Cuk, D. Rukavina
  • Periodicum Bio - logorum
  • 1991

Stimulatory effect of vasoactive intestinal peptide (VIP) on cyclic AMP production in rat peritoneal macrophages

J. J. Segura, J. M. Guerrero, R. Gobema, J. R. Calvo
  • Regulatory Peptides (In press)
  • 1991

vasoactive intestinal peptide binding sites in the thymus and bursa of Fabricius of the chick

D. Nohr, E. Weihe
  • Peptides
  • 1991

Imnumomodulation by somatostatin . Goberna , R . ( 198 1 )

S. P. Sreedharan
  • Interaction ofvasoacttve mtestmal pep - Advances in Immunology
  • 1990

stance P and somatostatin on immunoglobulin synthesis and proliferations by lymphocytes from Peyer’s patches, mesenteric lymph nodes and spleen

M. Muscettola, G. Grasso
  • Journal of Immunology
  • 1990