Somatostatin inhibition of VIP-and isoproterenol-stimulated cyclic AMP accumulation in dissociated cells from rat cerebral cortex

@article{Cols1990SomatostatinIO,
  title={Somatostatin inhibition of VIP-and isoproterenol-stimulated cyclic AMP accumulation in dissociated cells from rat cerebral cortex},
  author={Bego{\~n}a Col{\'a}s and Mariano L{\'o}pez Ruiz and Juan Carlos Mej{\'i}a Prieto and Eduardo Arilla},
  journal={Neuropeptides},
  year={1990},
  volume={15},
  pages={235-239}
}
Freshly dissociated cerebral cortex cells from adult rats have been used in the present study to determine if dual regulation of cyclic AMP levels by inhibitory and stimulatory agents can be expressed in the mature brain. Somatostatin, an inhibitory agent, barely affected the basal cyclic AMP metabolism while vasoactive intestinal peptide (VIP) and isoproterenol, two stimulatory agents enhanced cyclic AMP production. However, this increase was depressed by somatostatin, which decreased the… CONTINUE READING
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